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In terms of specific regulatory effects, the protective role of mitophagy is mainly reflected in a state of moderate activation: when cells are subjected to mild stress and mitochondria undergo local damage, mitophagy can specifically recognize and clear damaged, depolarized mitochondria, effectively reducing the abnormal release of ROS and the cytoplasmic leakage of mtDNA

The impact of aging endothelial cells has been explored using mouse models, revealing that mice with accelerated senescence exhibit endothelial cellular dysfunction, impaired relaxation, and interstitial fibrosis, leading to HFpEF

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